Interesting article on cream (Ann Fonfa says she heard of it years ago). Excuse the 'hyped' up title. Good information on eggplant/tomato/pepper-based product. Remember more antioxidants are helpful in reducing sunburn and cancer risk. See article below.
“Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.” Photochem. Photobiol. Sci., 2010, 9, 597’ DOI: 10.1039/b9pp00130a.
Albena T. Dinkova-Kostova, Jed W. Fahey, Andrea L. Benedict, Stephanie N. Jenkins, Lingxiang Ye, Scott L. Wehage and Paul Talalay.
This comes from the lab that first looked at broccoli and broccoli sprouts (Johns Hopkins, MD)
Unprotected prolonged exposure to sunlight raises the risk of ultraviolet (UV) radiation to cause or accelerate skin aging as well as skin cancer. Albena T. Dinkova-Kostova, from Johns Hopkins University (Maryland, USA), and colleagues fed broccoli sprout extracts, high in glucoraphanin, a precursor to compounds in broccoli that have been identified as potent anti-carcinogens, to laboratory mice previously exposed to UV radiation.
The researchers found that a daily dose of 10 moles of glucoraphanin inhibited the subsequent development of skin tumors, with skin tumor incidence reduced by 25% and tumor volume by 70%.
Dr. William Grant of the Sunlight, Nutrition and Health Research Center (SUNARC), San Francisco, suggests maintaining a high dietary antioxidant status in order to guard against skin cancer. (posted 6/05)
Protective Effects of Topical Antioxidants in Humans
Dreher F, Maibach H
Curr Probl Dermatol. 2001;29:157-164
Human studies have convincingly demonstrated pronounced photoprotective effects of 'natural' and synthetic antioxidants when applied topically before UVR exposure. Particularly with respect to UVB-induced skin damage such as erythema formation, the photoprotective effects of antioxidants are significant when applied in distinct mixtures in appropriate vehicles.
Topical application of such combinations may result in a sustained antioxidant capacity of the skin, possibly due to antioxidant synergisms. And, since UVA-induced skin alterations are believed to be largely determined by oxidative processes, topical administration of antioxidants might be particularly promising.
In fact, topical application of antioxidants or antioxidant mixtures resulted in a remarkable increase in the minimal dose to induce immediate pigment darkening after UVA exposure and diminished the severity of UVA-induced photodermatoses in humans.
In conclusion, regular application of skin care products containing antioxidants may be of the utmost benefit in efficiently preparing our skin against exogenous oxidative stressors occurring during daily life. Furthermore, sunscreening agents may also benefit from combination with antioxidants resulting in increased safety and efficacy of such photoprotective products.
Int J Oncol, 8/01
Green Tea EGCG on Mouse Skin Protective
Articles, studies, LINKS
Patterns of Recurrence After SNLB:Cutaneous Melanoma
Curcumin & Irreversible Growth Inhibition/Apoptosis:Melanoma
Diet & Risk of Malignant Melanoma
Symptoms Pts w/cncrrnt BioChemothrpy Malign Melanoma
Toenail Arsenic Content & Cutaneous Melanoma: Iowa
Lymphedema After Complete Node Dissection: Melanoma
Gray Hair Shares Genetic Root w/Melanoma
Canavaxin (TM) for Stage IV Melanoma CANCELLED
Risk of Melanoma & Vitamin A, Coffee, Alcohol
Wasabi product Shows Action in Melanoma Cells
Antiangiogenic: Andrographis paniculata extract & andrographolide
Melanoma Can Appear in 'Hidden' Places Too
Do Sunscreens Increase Risk of Melanoma in Populations Residing at Higher Latitudes?
Dispelling myth of “benign hair sign” for melanoma
Genetic Manifestation of Melanoma Linked to Geographic Location
Phtoochem Photobiol, 2001
Curr Probl Dermatol, 2001
Chemoprevention w/Alpha-tocopherol & Mice
Compound from Corn Lily For Skin Cancer
Skin Pharmacol Appl Skin Physiol,
Toxicol Lett, 2001
Dermatol Surg, 2001
Topical Vitamin C Stops Basal Cell Carcinoma
LINK for cream to TREAT
Non-Melanoma Skin Cancers
British J Cancer, 12/04
Basal Cell Ca Does Not Correlate with Most-Exposed Areas
Nature News Service, Dec 2001
Tanning Associated with Optimal Vit D Status
J Clinical Oncology, 1/02
Soc for Investigative Dermatology,
National Acad of Sciences, 8/02
Univ of Central Florida, 6/03
Book from Indian publishers
AACR Press Release, 10/03
Frontiers in Cancer Prevention Research, 2003
EGCG, Chemoprevention & Skin Ca
Chemopreventive Effects Betanin: Skin Ca (Mice)
Calcium Glucorate & Skin Tumors
Ultraviolet Rad B & Perillyl Alcohol
Thanks to www.ivanhoe.com
J Am Acad of Dermatology,
Skin Ca: Lack of Awareness in Minority Communities
Dermatology Technique not Good for Dark Skin
Locate their links here
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